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TNFSF11 (DMC267) IgG1 Chimeric mAb

Anti-TNFSF11 (DMC267) IgG1 Chimeric Monoclonal Antibody
5/5

¥3,900.00

Cat.#:  28175

   Size:   100 μg

In Stock

          Product Description          
目录:   28175
产品名称:   TNFSF11(DMC267) IgG1 Chimeric Monoclonal Antibody
基因符号:   CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
描述:    TNFSF11 antibody(DMC267) IgG1 Chimeric Monoclonal Antibody
背景:    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT:PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6; which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes; and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
经过测试的应用:    Flow Cyt
推荐稀释度:    Flow Cyt 1:100
种属反应性:    Rabbit
亚型:    Rabbit:Human Fc chimeric IgG1
纯化:    Purified from cell culture supernatant by affinity chromatography
种属反应性:    Human TNFSF11
成分:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with TNFSF11 (DMC267) on Expi293 cells transfected with human TNFSF11 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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