武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处 

邮箱: 2716620741@qq.com

咨询: 027 – 63497286 

英文
英文

PD-L1 (DM124) Rabbit mAb

Anti-PD-L1 (DM124) Rabbit Monoclonal Antibody
5/5

¥3,900.00

Cat.#:  28469

   Size:   100 μg

In Stock

          Product Description          
目录:   28469
产品名称:   PD-L1(DM124) Rabbit Monoclonal Antibody
基因符号:   PD-L1; CD274; B7-H1; PDCD1L1; PDCD1LG1
描述:    PD-L1 antibody(DM124) Rabbit Monoclonal Antibody
背景:    This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells; such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue; this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments; this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies; including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
经过测试的应用:    ELISA; Flow Cyt
推荐稀释度:    ELISA 1:5000-10000; Flow Cyt 1:100
种属反应性:    Rabbit
亚型:    Rabbit IgG
纯化:    Purified from cell culture supernatant by affinity chromatography
种属反应性:    Human PD-L1
成分:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human PD-L1 protein, mFc His tagged protein 11151 can bind Rabbit PD-L1 monoclonal antibody  (clone: DM124) in a linear range of 0.1-15 ng/ml.

Figure 2. Flow cytometry analysis with PD-L1  (DM124) on Expi293 cells transfected with human PD-L1 (Blue histogram) or Expi293 transfected with irrelevant protein(Red histogram).
          Publications