Human MRGPRX2 Full Length Protein

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Human MRGPRX2 Full Length Protein-Synthetic Nanodisc

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Cat.#: 11086

Size: 50 μg

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目录: 11086

产品名称: Human MRGPRX2 Full Length Protein

规格: 10 µg; 50 µg and 100 µg

基因符号: MGRG3; MRGX2

Target: MRGPRX2

UNIPROT ID: Q96LB1

描述: Human MRGPRX2 Full Length Protein-Synthetic Nanodisc

背景: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Species/Host: HEK293

Molecular Weight: The human full length MRGPRX2 protein has a MW of 37.1 kDa

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

储存和运输: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Protein Families: Druggable Genome, GPCR, Transmembrane

Protein Pathways: N.A.

Figure 1. Elisa plates were pre-coated with Flag Tag MRGPRX2-Nanodisc (0.2μg/per well). Serial diluted Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for Flag monoclonal antibody binding with MRGPRX2-Nanodisc is 1.523ng/ml.

Figure 2. Human MRGPRX2-Nanodisc, Flag Tag on SDS-PAGE

Arf6	Arl1	Arl3	Cdc42	Gα₁₂	Gα₁₃	Gα₁₄	Gα_i	Gα_o	Gα_q
Gα_s	Gα_z	Rab11	Rab12	Rab14	Rab17	Rab18	Rab25	Rab26	Rab28
Rab2A	Rab3	Rab30	Rab31	Rab35	Rab38	Rab39	Rab41	Rab4A	Rab5
Rab7	Rab8A	Rab9A	Ral	Rac1	Ran	Rap1	Ras	Rheb	RhoA	Sar1

Albumin	Apolipoprotein	BAG1	BMP3	Cystatin	EYA2
FASCIN	GAPDH	GRB7	KIM1	MUC1	ORAIL
RAC-8A	SEPTIN9	SLC7A5	SUMO	Survivin	TFF3
Vimentin	Transferrin	β-Actin	β-Tubulin

ABL	AKT	ALK	ATM	ß-CATENIN	BRAF	BRCA1
BRCA2	CTCF	CTNNB1	EGFR	ERBB2	FBXW7	FGFR1
GNAQ	HRAS	IDH	JAK2	KIT	MEK1	NFE2L2
NOTCH1	PIK3CA	PTEN	RAS	RET	RHEB	SMAD4
SMO	STK11	TP53

Rab5 -GTP IF, IHC and IP	Rap1-GTP IF, IHC and IP
Ral-GTP IF, IHC and IP	Ran-GTP IF, IHC and IP
Sar1-GTP IF, IHC and IP	Arf6-GTP IF, IHC and IP
Rab11-GTP IF, IHC and IP

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