NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$389.00
Cat.#: 12216 |
Product Name: Mouse AXL Protein |
Size : 10 µg, 50 µg and 100 µg |
Synonyms: Ark;Ufo;Tyro7 |
Target: AXL |
UNIPROT ID: Q00993 |
Description: Recombinant mouse AXL protein with C-terminal 10xHis tag |
Background: Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; myeloid cell homeostasis; and negative regulation of tumor necrosis factor production. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022] |
Species/Host: HEK293 |
Molecular Weight: The protein has a predicted molecular mass of 47.8 kDa after removal of the signal peptide. The apparent molecular mass of mAXL-His is approximately 55-70 kDa due to glycosylation. |
Molecular Characterization: Mouse AXL(Ala19-Pro443) 10×His tag |
Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Mouse AXL Protein, His Tag on SDS-PAGE under reducing condition. |