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Her3 (DM175) Rabbit mAb

Anti-Her3 (DM175) Rabbit Monoclonal Antibody
5/5

¥3,900.00

Cat.#:  28518

   Size:   100 μg

In Stock

          Product Description          
目录:   28518
产品名称:   Her3(DM175) Rabbit Monoclonal Antibody
基因符号:   HER3; ERBB3
描述:    Her3 antibody(DM175) Rabbit Monoclonal Antibody
背景:    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However; it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and:or overexpression of its protein have been reported in numerous cancers; including prostate; bladder; and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported; but they have not been thoroughly characterized.
经过测试的应用:    ELISA; Flow Cyt
推荐稀释度:    ELISA 1:5000-10000; Flow Cyt 1:100
种属反应性:    Rabbit
亚型:    Rabbit IgG
纯化:    Purified from cell culture supernatant by affinity chromatography
种属反应性:    Human HER3
成分:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Her3 (DM175) on Expi293 cells transfected with human Her3 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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