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HER2 (DMC369) IgG1 Chimeric mAb

Anti-HER2 (DMC369) IgG1 Chimeric Monoclonal Antibody
5/5

¥3,900.00

Cat.#:  28202

   Size:   100 μg

In Stock

          Product Description          
目录:   28202
产品名称:   HER2(DMC369) IgG1 Chimeric Monoclonal Antibody
基因符号:   ERBB2;CD340;HER-2:neu;HER2;MLN19;NEU;NGL;TKR1
描述:    HER2 antibody(DMC369) IgG1 Chimeric Monoclonal Antibody
背景:    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However; it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer; stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways; such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported; with the most common allele; Ile654:Ile655; shown here. Amplification and:or overexpression of this gene has been reported in numerous cancers; including breast and ovarian tumors. Alternative splicing results in several additional transcript variants; some encoding different isoforms and others that have not been fully characterized.
经过测试的应用:    Flow Cyt
推荐稀释度:    Flow Cyt 1:100
种属反应性:    Rabbit
亚型:    Rabbit:Human Fc chimeric IgG1
纯化:    Purified from cell culture supernatant by affinity chromatography
种属反应性:    Human Her2
成分:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with HER2 (DMC369) on Expi293 cells transfected with human HER2 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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