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GPC3 (DMC371) IgG1 Chimeric mAb

Anti-GPC3 (DMC371) IgG1 Chimeric Monoclonal Antibody
5/5

¥3,900.00

Cat.#:  28204

   Size:   100 μg

In Stock

          Product Description          
目录:   28204
产品名称:   GPC3(DMC371) IgG1 Chimeric Monoclonal Antibody
基因符号:   DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1
描述:    GPC3 antibody(DMC371) IgG1 Chimeric Monoclonal Antibody
背景:    Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26; and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome; also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq; Sep 2009] References: Fu Ying,Urban Daniel J,Nani Roger R et al. Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.[J] .Hepatology; 2019; 70: 563-576. Zhang Yi-Fan,Ho Mitchell,Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma.
经过测试的应用:    Flow Cyt
推荐稀释度:    Flow Cyt 1:100
种属反应性:    Rabbit
亚型:    Rabbit:Human Fc chimeric IgG1
纯化:    Purified from cell culture supernatant by affinity chromatography
种属反应性:    Human GPC3
成分:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
储存和运输:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry data of serially titrated GPC3 monoclonal antibody (DMC371) on Huh7 cell line.
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