| 目录: 11039 |
| 产品名称: Human CMTM6 Full Length Protein |
| 规格: 10 µg, 50 µg and 100 µg |
| 基因符号: CKLFSF6; PRO2219 |
| Target: CMTM6 (CKLF like MARVEL transmembrane domain containing 6, chemokine-like factor superfamily 6) |
| UNIPROT ID: Q9NX76 |
| 描述: Human CMTM6 full length protein-synthetic nanodisc |
| 背景: CMTM6 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3.
CMTM6 is involved in the immune-related and metabolism-related pathways. It increases the expression of programmed cell death 1 ligand 1 protein, thereby impairing T cell function. Various manufactured therapeutic monoclonal antibody drugs, e.g. pembrolizumab, atezolizumab, durvalumab, nivolumab, and avelumab, bind to and inhibit the stimulation of PD-1 on CD8+ T cells by PD-L1. In effect, they block the ability of CMTMT6 to suppress PDL1/PD-1-stimulated CD8+ T-cell immune responses against tumor cells. Elevated expression of CMTM6 in glioma and head and neck squamous cell carcinoma was shown to be associated with a poor prognosis; in addition, CMTM6 is also a potential therapeutic target for triple-negative breast cancer. |
| Species/Host: HEK293 |
| Molecular Weight: The human full length CMTM6 protein has a MW of 20.4 kDa |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure1. Elisa plates were pre-coated with Flag Tag CMTM6-Nanodisc (0.2 µg/per well). Serial diluted Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for Flag monoclonal antibody binding with CMTM6-Nanodisc is 4.393ng/ml. |
Figure2. Human CMTM6-Nanodisc, Flag Tag on SDS-PAGE |
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