武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处 

邮箱: 2716620741@qq.com

咨询: 027 – 63497286 

英文
英文

Human CHRM2 Full Length Protein

Human CHRM2 Full Length Protein-Synthetic Nanodisc
5/5

¥38,200.00

Cat.#:  11092

   Size:   50 μg

In Stock

          Product Description          
目录:     11092
产品名称:   Human CHRM2 Full Length Protein
规格:    10 µg; 50 µg and 100 µg
基因符号:   HM2
Target:    CHRM2
UNIPROT ID:    P08172
描述:    Human CHRM2 Full Length Protein-Synthetic Nanodisc
背景:     The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Species/Host:    HEK293
Molecular Weight:    The human full length CHRM2 protein has a MW of 51.7 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Protein Families:    Druggable Genome, GPCR, Transmembrane
Protein Pathways:    Calcium signaling pathway, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

Figure 1. Elisa plates were pre-coated with Flag Tag CHRM2-Nanodisc (0.2μg/per well). Serial diluted Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for Flag monoclonal antibody binding with CHRM2-Nanodisc is 13.52ng/ml.

Figure 2. Human CHRM2-Nanodisc, Flag Tag on SDS-PAGE
          Publications