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PAPPA-AS1 Rabbit pAb

Anti-PAPPA-AS1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221501

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221501
Product Name:   Anti-PAPPA-AS1 Rabbit Polyclonal Antibody
Synonyms:   DIPAS; TAF4B; PAPPAS; TAF2C2; PAPPAAS; PAPPA-AS; TAFII105; NCRNA00156
UNIPROT ID:   Q5QFB9 (Gene Accession – AAV41519 )
Background:    PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).
Immunogen:    Synthetic peptide of human PAPPA-AS1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 221501(PAPPA-AS1 Antibody) at a dilution of 1/35(Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the synthetic peptide and then with 221501(Anti-PAPPA-AS1 Antibody) at dilution 1/35.
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