Cat.#: S220422 |
Product Name: Anti-NOD2 Rabbit Polyclonal Antibody |
Synonyms: CD; ACUG; BLAU; IBD1; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1 |
UNIPROT ID: Q9HC29 (Gene Accession – NP_071445 ) |
Background: This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. |
Immunogen: Synthetic peptide of human NOD2 |
Applications: ELISA, IHC |
Recommended Dilutions: IHC: 25-100; ELISA: 1000-2000 |
Host Species: Rabbit |
Clonality: Rabbit Polyclonal |
Isotype: Immunogen-specific rabbit IgG |
Purification: Antigen affinity purification |
Species Reactivity: Human |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
Research Areas: Cancer |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 220422(NOD2 Antibody) at a dilution of 1/20(Cytoplasm). | In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 220422(Anti-NOD2 Antibody) at dilution 1/20. | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 220422(Anti-NOD2 Antibody) at a dilution of 1/20. | In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with synthetic peptide and then with D261510(Anti-NOD2 Antibody) at dilution 1/20. |
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