关于 NewEast Biosciences
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
¥4,050.00
货号: 26103 | |
规格: 100 µL | |
描述: MMAE Rabbit Monoclonal antibody(9C4) | |
背景: Monomethyl auristatin E (MMAE), a potent mitotic inhibitor derived from dolastatin 10, plays a pivotal role in antibody-drug conjugates (ADCs) for cancer therapy. ADCs precisely target cancer cells, minimizing collateral damage. However, ADC development requires thorough pharmacokinetic and safety assessments. Our specialized MMAE antibodies streamline this process, facilitating PK analysis and safety evaluation. These antibodies are crucial tools for optimizing ADCs, ensuring their effectiveness and safety in revolutionizing cancer treatment. | |
免疫原: Monomethyl auristatin E | |
经过测试的应用: ELISA | |
推荐稀释度: ELISA 1:5000-10000 | |
浓度: 100 ug | |
种属反应性: Rabbit | |
克隆性: Rabbit Monoclonal | |
Clone ID: 9C4 | |
亚型: Rabbit IgG | |
纯化:: Purified from cell culture supernatant by affinity chromatography | |
Formulation & Reconstitution:Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. | |
储存条件:: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | |
![]() Figure 1. Elisa plates were pre-coated with IgG-MMAE (0.2 μg/per well). Serial diluted MMAE monoclonal antibody (26103) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for MMAE monoclonal antibody binding with IgG-MMAE is 2.370 ng/ml. |