NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.
Exosomes (EXO) are secreted membrane nanoparticles formed by fusion of multivesicular bodies (MVBs) with the plasma membrane. The size of exosomes is about 30-150nm. Exosomes can be purified from in vitro cultures of cells. Like VLPs, EXO also shows outstanding immunogenicity and have the membrane structure close to that of the native plasma membrane.
Overexpressed membrane proteins (MPs) were inserted in the host cell membrane and secreted out as Exosomes which can be purified and used for a series of downstream studies. Unlike VLPs, the purified EXO has minimal cytotoxicity. However, not all MPs can be included in EXO and secreted into medium.