Cat.#: S222328 |
Product Name: Anti-SELENOM Rabbit Polyclonal Antibody |
Synonyms: SELM; SEPM |
UNIPROT ID: Q8WWX9 (Gene Accession – NP_536355 ) |
Background: The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3′ UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. |
Immunogen: Synthetic peptide of human SELENOM |
Applications: ELISA, IHC |
Recommended Dilutions: IHC: 25-100; ELISA: 5000-10000 |
Host Species: Rabbit |
Clonality: Rabbit Polyclonal |
Isotype: Immunogen-specific rabbit IgG |
Purification: Antigen affinity purification |
Species Reactivity: Human, Mouse |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol |
Research Areas: Metabolism |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 222328(SELENOM Antibody) at a dilution of 1/30(Cytoplasm). | In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 222328(Anti-SELENOM Antibody) at dilution 1/30. | The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 222328(Anti-SELENOM Antibody) at a dilution of 1/30. | In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with synthetic peptide and then with D264401(Anti-SELENOM Antibody) at dilution 1/30. |
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