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Human FZD7 Full Length Protein

Human FZD7 Full Length Protein-Synthetic Nanodisc
5/5

¥38,200.00

Cat.#:  11090

   Size:   50 μg

In Stock

          Product Description          
目录:     11090
产品名称:   Human FZD7 Full Length Protein
规格:    10 µg; 50 µg and 100 µg
基因符号:   FzE3
Target:    FZD7
UNIPROT ID:    O75084
描述:    Human FZD7 Full Length Protein-Synthetic Nanodisc
背景:     Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Species/Host:    HEK293
Molecular Weight:    The human full length FZD7 protein has a MW of 63.6 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
储存和运输:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Protein Families:    Druggable Genome, Transmembrane
Protein Pathways:    Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway

Figure 1. Elisa plates were pre-coated with Flag Tag FZD7-Nanodisc (0.2μg/per well). Serial diluted Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for Flag monoclonal antibody binding with FZD7-Nanodisc is 1.783ng/ml.

Figure 2. Human FZD7-Nanodisc, Flag Tag on SDS-PAGE
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